{"id":5553,"date":"2018-04-22T19:51:22","date_gmt":"2018-04-22T19:51:22","guid":{"rendered":"http:\/\/braintest.com\/?post_type=kbe_knowledgebase&#038;p=5553"},"modified":"2020-03-09T22:51:08","modified_gmt":"2020-03-09T22:51:08","slug":"drugs-approved-treat-alzheimers","status":"publish","type":"kbe_knowledgebase","link":"https:\/\/braintest.com\/drugs-approved-treat-alzheimers\/","title":{"rendered":"What Drugs Are Approved to Treat Alzheimer\u2019s?"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Although th<\/span><span style=\"font-weight: 400;\">ere is\u00a0currently no cure for Alzheimer\u2019s, various medications are still available. These drugs target specific symptoms and help to improve a patient\u2019s quality of life. In some cases, these medications can lead to improvements that last several years.<\/span><\/p>\n<p>Currently, there are five FDA-approved drugs. These include donepezil, galantamine, memantine, rivastigmine, as well as donepezil with memantine.<\/p>\n<p>Over the coming weeks, we will highlight each of these in greater detail.<\/p>\n<h1><b>Different Drugs for Different Stages<\/b><\/h1>\n<p>Since Alzheimer\u2019s is a progressive disease, patients experience different stages. These range from mild to severe based on a number of variables. These stages not only differ in terms of their symptoms but also in how they are treated.<\/p>\n<p>Of course, these \u2018stages\u2019 are not exact. One patient may showcase unique symptoms in comparison to another patient, which\u00a0is why a personalized treatment plan is often required.\u00a0<\/p>\n<p>However, in terms of drugs listed above, they tend to be prescribed based on what they were approved for. Donepezil, for instance, is approved for all stages whereas memantine is approved for the more moderate to severe stages.<\/p>\n<h2><b>How These Drugs Work<\/b><\/h2>\n<p>Classified into two key groups, these five medications can be categorized into cholinesterase inhibitors and memantine. These drugs are able to treat different symptoms based on how they influence the brain and alter key neurotransmitters.<\/p>\n<ul>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\"><strong>Cholinesterase inhibitors<\/strong> \u2014 Those living with Alzheimer\u2019s experience a decrease in acetylcholine levels, impacting judgment, memory, and attention. These drugs boost levels of acetylcholine by preventing this chemical from breaking down in the brain. <\/span>\n<ul>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Drugs included: Donepezil (brand name: Aricept), galantamine (brand name: Razadyne), and Rivastigmine (brand nam<\/span><span style=\"font-weight: 400;\">e: Exel<\/span><span style=\"font-weight: 400;\">on). <\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\"><strong>Memantine<\/strong> \u2014 Generally prescribed for the later stages, memantine (brand name: Namenda) targets another brain chemical, glutamate. There is also a combination of memantine and donepezil known by the brand name Namzaric. <\/span><\/li>\n<\/ul>\n<p>All five of these medications promote positive effects, however, they may also lead to some undesirable effects. It is also important to note that those who suffer from cardiac arrhythmias should not take cholinesterase. Once again, each individual patient should work with their physician to develop a treatment plan that suits their unique needs.<\/p>\n<h2><b>Could This New <\/b><b>Exp<\/b><b>erimental Drug Halt Alzheimer\u2019s?<\/b><\/h2>\n<p>All of the approved medications that are currently available do not truly treat this disease. Instead, they simply mask symptoms that progressively get worse. However, there is a new drug that is currently being tested, which is known as Aducanumab.<\/p>\n<p><span style=\"font-weight: 400;\">In <\/span><a href=\"http:\/\/time.com\/5159880\/please-be-the-drug\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">a recent TIM<\/span><span style=\"font-weight: 400;\">E articl<\/span><span style=\"font-weight: 400;\">e<\/span><\/a><span style=\"font-weight: 400;\">, 77-year old Peter is just one of 2,700 people who has volunteered to test\u00a0this new drug \u2014 one that researchers believe is the first of its kind. In fact, it has been reported that this drug may be the first to actually halt the progression of Alzheimer\u2019s disease.<\/span><\/p>\n<p>During this study, which is currently ongoing, two-thirds of the volunteers will be given the drug. The remaining one-third will be given a placebo. None of the volunteers know what they received and will not find out until 18 months have passed.<\/p>\n<p>Regardless of whether a patient receives Aducanumab or the placebo, an injection is administered monthly. As stated, this will continue for a year and a half. After this period is over, volunteers such as Peter are guaranteed to receive the drug for an additional two years.<\/p>\n<h3><b>The First Phase Has Shown Promising Results<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">After collecting data for 36 months, the potential effects of aducanumab <\/span><a href=\"http:\/\/n.neurology.org\/content\/90\/15_Supplement\/S2.004\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">have been published<\/span><\/a><span style=\"font-weight: 400;\"> in <\/span><i><span style=\"font-weight: 400;\">Neurology<\/span><\/i><span style=\"font-weight: 400;\">. This first phase is being referred to <\/span><span style=\"font-weight: 400;\">as PRIME, which will b<\/span><span style=\"font-weight: 400;\">e followed by <\/span><span style=\"font-weight: 400;\">ENGAGE and EMERGE. What th<\/span><span style=\"font-weight: 400;\">e researchers have found, was that patients who were treated with the drug experienced a decrease in amyloid plaque levels. This decrease was expressed in a dose- and time-dependent manner.<\/span><\/p>\n<p>Although these effects are promising, it is still far too early to make any conclusions.<\/p>\n<h2><b>Early Screening Is The Smart Thing To Do<\/b><\/h2>\n<p>Like many drugs tested before aducanumab, these trials often target patients who are suffering from mild to moderate Alzheimer\u2019s. This means that those who are diagnosed early, often have more options in terms of their treatment plan. This further supports the best practice of getting screened early.<\/p>\n<p>If you are concerned about your thinking or memory, or want to establish a baseline from which to monitor your cognition, <strong><a href=\"https:\/\/go.onelink.me\/Rk33?pid=blog&#038;c=approved-alz-drugs-1\">BrainTest<\/a><\/strong> is the application for you. <a href=\"https:\/\/go.onelink.me\/Rk33?pid=blog&#038;c=approved-alz-drugs-1\"><strong>BrainTest<\/strong><\/a> is the same kind of screening test at doctor&#8217;s offices, but one that is uniquely designed to screen for early changes in cognition associated with Alzheimer&#8217;s Disease, Dementia, and Mild Cognitive Impairment.<\/p>\n<p><a href=\"https:\/\/go.onelink.me\/Rk33?pid=blog&#038;c=approved-alz-drugs-1\"><strong>BrainTest<\/strong><\/a> can be taken in the privacy of your own home, anonymously scored at our centralized scoring core-lab, and result videos delivered inside the application feature an explanation of your score from a Board Certified Physician. When you are ready, these results can be shared with your doctor to help start the conversation about possible treatments.\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Although there is\u00a0currently no cure for Alzheimer\u2019s, various medications are still available. These drugs target specific symptoms and help to improve a patient\u2019s quality of life. In some cases, these medications can lead to improvements that last several years. Currently, there are five FDA-approved drugs. These include donepezil, galantamine, memantine,<\/p>\n","protected":false},"author":5,"featured_media":7984,"comment_status":"open","ping_status":"closed","template":"","kbe_taxonomy":[36],"kbe_tags":[],"class_list":["post-5553","kbe_knowledgebase","type-kbe_knowledgebase","status-publish","has-post-thumbnail","hentry","kbe_taxonomy-alzheimers"],"uagb_featured_image_src":{"full":["https:\/\/braintest.com\/wp-content\/uploads\/blur-box-capsules-close-up-593451.jpg",1920,1198,false],"thumbnail":["https:\/\/braintest.com\/wp-content\/uploads\/blur-box-capsules-close-up-593451-300x224.jpg",300,224,true],"medium":["https:\/\/braintest.com\/wp-content\/uploads\/blur-box-capsules-close-up-593451-300x187.jpg",300,187,true],"medium_large":["https:\/\/braintest.com\/wp-content\/uploads\/blur-box-capsules-close-up-593451.jpg",1920,1198,false],"large":["https:\/\/braintest.com\/wp-content\/uploads\/blur-box-capsules-close-up-593451-1024x639.jpg",1024,639,true],"1536x1536":["https:\/\/braintest.com\/wp-content\/uploads\/blur-box-capsules-close-up-593451.jpg",1536,958,false],"2048x2048":["https:\/\/braintest.com\/wp-content\/uploads\/blur-box-capsules-close-up-593451.jpg",1920,1198,false],"rp-thumbnail":["https:\/\/braintest.com\/wp-content\/uploads\/blur-box-capsules-close-up-593451-160x100.jpg",160,100,true],"product":["https:\/\/braintest.com\/wp-content\/uploads\/blur-box-capsules-close-up-593451-310x310.jpg",310,310,true]},"uagb_author_info":{"display_name":"Krista Hillis","author_link":"https:\/\/braintest.com\/es\/author\/kristahillis\/"},"uagb_comment_info":0,"uagb_excerpt":"Although there is\u00a0currently no cure for Alzheimer\u2019s, various medications are still available. These drugs target specific symptoms and help to improve a patient\u2019s quality of life. In some cases, these medications can lead to improvements that last several years. Currently, there are five FDA-approved drugs. These include donepezil, galantamine, memantine,","_links":{"self":[{"href":"https:\/\/braintest.com\/es\/wp-json\/wp\/v2\/kbe_knowledgebase\/5553","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/braintest.com\/es\/wp-json\/wp\/v2\/kbe_knowledgebase"}],"about":[{"href":"https:\/\/braintest.com\/es\/wp-json\/wp\/v2\/types\/kbe_knowledgebase"}],"author":[{"embeddable":true,"href":"https:\/\/braintest.com\/es\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/braintest.com\/es\/wp-json\/wp\/v2\/comments?post=5553"}],"version-history":[{"count":18,"href":"https:\/\/braintest.com\/es\/wp-json\/wp\/v2\/kbe_knowledgebase\/5553\/revisions"}],"predecessor-version":[{"id":7983,"href":"https:\/\/braintest.com\/es\/wp-json\/wp\/v2\/kbe_knowledgebase\/5553\/revisions\/7983"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/braintest.com\/es\/wp-json\/wp\/v2\/media\/7984"}],"wp:attachment":[{"href":"https:\/\/braintest.com\/es\/wp-json\/wp\/v2\/media?parent=5553"}],"wp:term":[{"taxonomy":"kbe_taxonomy","embeddable":true,"href":"https:\/\/braintest.com\/es\/wp-json\/wp\/v2\/kbe_taxonomy?post=5553"},{"taxonomy":"kbe_tags","embeddable":true,"href":"https:\/\/braintest.com\/es\/wp-json\/wp\/v2\/kbe_tags?post=5553"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}