{"id":4789,"date":"2018-01-04T19:45:42","date_gmt":"2018-01-04T19:45:42","guid":{"rendered":"http:\/\/braintest.com\/?p=4789"},"modified":"2019-12-06T19:36:38","modified_gmt":"2019-12-06T19:36:38","slug":"diabetes-drug-shown-improve-memory-loss-mice","status":"publish","type":"post","link":"https:\/\/braintest.com\/es\/diabetes-drug-shown-improve-memory-loss-mice\/","title":{"rendered":"A Diabetes Drug Has Been Shown to Improve Memory Loss in Mice"},"content":{"rendered":"<p>With 2017 behind us, it is exciting to think about the year ahead.<\/p>\n<p>What discoveries will we make \u2014 and how will advancing research influence dementia and Alzheimer&#8217;s patients?<\/p>\n<p>According to a recent study, there is hope. A type 2 diabetes drug was shown to significantly reverse memory loss in mice. Could this be a breakthrough within Alzheimer&#8217;s research?<\/p>\n<h1>Study Finds \u2014 Diabetes Drug Improves Alzheimer&#8217;s in Mice<\/p>\n<\/h1>\n<p>As published in <em>Brain Research<\/em>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29050859\" target=\"_blank\" rel=\"noopener noreferrer\">this recent study<\/a> was funded in part by the Alzheimer&#8217;s Society. Since there has been no new, innovative treatments for 15+ years, this research is both exciting and promising.<\/p>\n<p>Focusing on growth factors, this drug has been shown to protect the brain against degeneration. Combining GLP-1, GIP and Glucagon, this drug may help overcome growth factor signalling depletion \u2014 a key factor in the development of dementia.<\/p>\n<p>An older version of this drug was studied in the past, showing positive results in regards to Alzheimer&#8217;s and mood disorders. When studied more recently, it was shown to:<\/p>\n<ul>\n<li>Increase brain factor growth<\/li>\n<li>Reduce amyloid plaque levels<\/li>\n<li>Reduce inflammation and oxidative stress in the hippocampus<\/li>\n<li>Slow down the rate of nerve cell loss<\/li>\n<\/ul>\n<p>The researchers concluded that triple receptor agonists are promising when designing potential future treatment strategies.<\/p>\n<h1>Diabetes and Alzheimer&#8217;s Research<\/h1>\n<p>It is well understood that type 2 diabetes is a risk factor for Alzheimer&#8217;s disease. This is why Alzheimer&#8217;s researchers are so interested in the prognosis of diabetes \u2014 as well as available treatment methods.<\/p>\n<p>In December 2017, professors from the United States and Japan won an award for their research regarding type 2 diabetes and Alzheimer&#8217;s. They were announced as the winners of the 2018 Breakthrough Prize in Life Sciences, based on their research on the unfolded protein response.<\/p>\n<p>Their finding has helped scientists and researchers learn more not only about type 2 diabetes and Alzheimer&#8217;s, but also cancer. In Alzheimer&#8217;s, when there are too many unfolded proteins in the brain, cell death occurs. Over time, this results in memory loss.<\/p>\n<p><a href=\"https:\/\/www.diabetes.co.uk\/news\/2017\/dec\/professors-scoop-award-for-protein-breakthrough-in-type-2-diabetes-and-alzheimers-97847575.html\" target=\"_blank\" rel=\"noopener noreferrer\">As stated<\/a> by the Chancellor of UC San Francisco, \u00abThis is an example of how decoding the basic principles of life can fundamentally improve our understanding of human health.\u00bb<\/p>\n<p>Within another key<a href=\"https:\/\/www.nih.gov\/news-events\/news-releases\/higher-brain-glucose-levels-may-mean-more-severe-alzheimers\" target=\"_blank\" rel=\"noopener noreferrer\">\u00a0study<\/a>, published in <em>Alzheimer&#8217;s &#038; Dementia<\/em>, it was found that high concentrations of glucose in brain tissue can result from abnormal glucose metabolism. <a href=\"https:\/\/www.alzheimers.net\/diabetes-of-the-brain\/\" target=\"_blank\" rel=\"noopener noreferrer\">As expressed<\/a> by the director of behavioral neurology at Allegheny General Hospital in Pittsburg, \u00abThe same things that are bad for the heart are bad for the brain.\u00bb<\/p>\n<p>This is why preventative measures are so imperative. Once there is damage to the brain, it is much harder to gain back function.<\/p>\n<h1>Reducing Your Risk of Alzheimer&#8217;s By Preventing Type 2 Diabetes<\/h1>\n<p>Alzheimer&#8217;s is often referred to as &#8216;type 3 diabetes&#8217; \u2014 based on chronic insulin resistance in the brain. The link between diabetes and Alzheimer&#8217;s continues to grow stronger. Considering more than 1 out of 3 American adults is living with prediabetes, increased awareness is critical.<\/p>\n<p>In fact, according to the <a href=\"https:\/\/www.cdc.gov\/diabetes\/basics\/prediabetes.html\" target=\"_blank\" rel=\"noopener noreferrer\">Center for Disease Control and Prevention<\/a>, 90 percent of those with prediabetes, do not know that they are living with higher than normal blood sugar levels.<\/p>\n<p>The good news?<\/p>\n<p>Type 2 diabetes is largely preventable.<\/p>\n<p><a href=\"https:\/\/www.hsph.harvard.edu\/nutritionsource\/diabetes-prevention\/preventing-diabetes-full-story\/\" target=\"_blank\" rel=\"noopener noreferrer\">As stated by<\/a> Harvard School of Public Health, approximately 9 out of 10 cases is avoidable. By addressing one&#8217;s weight, level of physical activity, diet, and smoking habits, this life-changing disease could be prevented.<\/p>\n<h1>Tips to Reduce Your Risk<\/h1>\n<p>When it comes to the onset of diabetes, although your genes can influence your risk, they tend to take a back seat in comparison to lifestyle and behavioral factors. In order to actively protect yourself, here are some simple, effective steps to implement into your current routine.<\/p>\n<ul>\n<li><strong>Manage your weight<\/strong> \u2014 Obesity is the most important factor in regards to the cause of type 2 diabetes. In comparison to someone that maintains a healthy weight, obese individuals increase their risk by 20 to 40 times. Losing between 7 to 10 percent of your current weight could cut your risk of developing type 2 diabetes in half.<\/li>\n<li><strong>Get moving<\/strong> \u2014 Regular exercise is not only important for weight loss, but working your muscles can actually improve your body&#8217;s ability to absorb glucose. In addition, regular physical activity supports heart health, which in turn, supports neural health.<\/li>\n<li><strong>Alter your diet<\/strong> \u2014 Consuming a balanced diet is imperative. Cut out refined carbohydrates and consume more whole grains, low-glycemic fruits, and vegetables. The key is to reduce spikes in blood sugar and insulin. You should also consume more healthy fats, avoiding fast food, packaged baked goods, margarine&#8217;s, and other foods made with partially hydrogenated vegetable oil.<\/li>\n<li><strong>Drink more water and tea<\/strong> \u2014 Within the <a href=\"https:\/\/www.nhs3.org\/index.php\/our-story\/20-nurses-health-study-2\" target=\"_blank\" rel=\"noopener noreferrer\">Nurses&#8217; Health Study II<\/a>, it was found that women who drank one or more sugar-sweetened drinks daily, showcased an 83 percent higher risk of type 2 diabetes, in comparison to women who drank less than one of these beverages a month. Water is, of course, an excellent replacement \u2014 but so are herbal teas. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27925140\" target=\"_blank\" rel=\"noopener noreferrer\">Within one study<\/a>, regular tea consumption was also shown to lower risk of neurocognitive decline.<\/li>\n<li><strong>Quit smoking<\/strong> \u2014 In comparison to nonsmokers, smokers are approximately 50 percent more likely to develop diabetes. This risk increases for heavy smokers.<\/li>\n<\/ul>\n<p><strong>Bottom line: In order to reduce your risk of type 2 diabetes and in turn, Alzheimer&#8217;s, you need to remain lean and active.\u00a0<\/strong><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>With 2017 behind us, it is exciting to think about the year ahead. What discoveries will we make \u2014 and how will advancing research influence dementia and Alzheimer&#8217;s patients? According to a recent study, there is hope. A type 2 diabetes drug was shown to significantly reverse memory loss in<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[61,65],"tags":[],"class_list":["post-4789","post","type-post","status-publish","format-standard","hentry","category-alzheimers","category-brain-health"],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"rp-thumbnail":false,"product":false},"uagb_author_info":{"display_name":"Krista Hillis","author_link":"https:\/\/braintest.com\/es\/author\/kristahillis\/"},"uagb_comment_info":0,"uagb_excerpt":"With 2017 behind us, it is exciting to think about the year ahead. What discoveries will we make \u2014 and how will advancing research influence dementia and Alzheimer&#8217;s patients? According to a recent study, there is hope. A type 2 diabetes drug was shown to significantly reverse memory loss in","_links":{"self":[{"href":"https:\/\/braintest.com\/es\/wp-json\/wp\/v2\/posts\/4789","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/braintest.com\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braintest.com\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braintest.com\/es\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/braintest.com\/es\/wp-json\/wp\/v2\/comments?post=4789"}],"version-history":[{"count":4,"href":"https:\/\/braintest.com\/es\/wp-json\/wp\/v2\/posts\/4789\/revisions"}],"predecessor-version":[{"id":4800,"href":"https:\/\/braintest.com\/es\/wp-json\/wp\/v2\/posts\/4789\/revisions\/4800"}],"wp:attachment":[{"href":"https:\/\/braintest.com\/es\/wp-json\/wp\/v2\/media?parent=4789"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braintest.com\/es\/wp-json\/wp\/v2\/categories?post=4789"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braintest.com\/es\/wp-json\/wp\/v2\/tags?post=4789"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}