{"id":4844,"date":"2018-01-17T16:28:20","date_gmt":"2018-01-17T16:28:20","guid":{"rendered":"http:\/\/braintest.com\/?p=4844"},"modified":"2019-12-06T19:38:39","modified_gmt":"2019-12-06T19:38:39","slug":"drug-modelled-curcumin-slow-progression-alzheimers","status":"publish","type":"post","link":"https:\/\/braintest.com\/es\/drug-modelled-curcumin-slow-progression-alzheimers\/","title":{"rendered":"Could a Drug Modelled After Curcumin Slow Down the Progression of Alzheimer’s?"},"content":{"rendered":"

In a recent article<\/a>, I discussed Pfizer’s surprising announcement. Although the pharma giant stated that they will be backing out of Alzheimer’s research, I stressed the fact that this is not the end.<\/p>\n

Disheartening, yes \u2014 but Alzheimer’s research will continue.<\/p>\n

Based on recent findings, there is a glimmer of hope. An experimental drug, known as J147 was shown to treat Alzheimer’s disease and reverse signs of aging in mice. Nearly ready for clinical human trials, researchers around the globe will continue the fight against this neurodegenerative disease.<\/p>\n

Study Finds \u2014 Alzheimer’s Drug Makes Mice More Youthful<\/h1>\n

As published in Aging Cell<\/i>, this recent study<\/a> found that the drug J147 binds to protein within the mitochondria. This organelle generates energy in cells and helped scientists solve a key puzzle. By understanding what J147 does, the researchers can now begin clinical trials.<\/p>\n

This is a prime example of how dedicated research leads to progress. This group of researchers first developed J147 in 2011. After screening plants with the ability to reverse cellular and molecular aging in the brain, they created a modified version of a molecule found in curcumin. This chemical is most often associated with turmeric, and its ability to reduce inflammation.<\/p>\n

Based on their findings, J147 may not only\u00a0reduce the impact of\u00a0Alzheimer’s but other age-associated diseases as well. As stated by the lead researcher, \u201cBy targeting aging, we may be able to slow down many pathological conditions associated with old-age.\u201d<\/p>\n

A 2010 review<\/a> explored the connection between curcumin and aging. As published in Current Pharmaceutical Design<\/i>, the evolutionary theory of aging is based on the relationship between body maintenance and investments in reproduction. This process is a result of lifelong molecular damage due to oxidative stress produced in the mitochondria. DNA replication errors are also said to play a key role.<\/p>\n

Since aging is plastic, we can manipulate this process; and researchers believe that reducing inflammation may be the first step. In their review, they highlight the possibility of curcumin as a potent anti-inflammatory and antioxidant agent.<\/p>\n

More on the Power of Curcumin<\/h1>\n

Around the globe, there are more than 1000 published studies on the effects of curcumin\u00a0in regards to various diseases. As discussed, J147 is modelled after curcumin \u2014 which is no stranger to Alzheimer’s research. It has been extensively based on its antioxidant and anti-inflammatory properties.<\/p>\n

India has a very low prevalence of Alzheimer’s, which may be due to a specific intake of food.\u00a0Used in Indian cuisine for at least 2500 years, turmeric has a long medicinal history in South Asia. One theory is that the high daily consumption of turmeric supports prevention.<\/p>\n

In India, the prevalence of Alzheimer’s among adults aged 70-79 years is 4.4 times less<\/a> than the same aged group in the United States. Genetics may play a role, but diet remains a key area of interest. In addition, animal studies have found<\/a> that curcumin may have a direct effect on amyloid pathology in Alzheimer’s.<\/p>\n

Curcumin’s Effects on Fruit Flies<\/h1>\n

In 2012, a curcumin-based study<\/a> was published in PloS ONE<\/i>. It was found that curcumin enhanced activity and prolonged the life of transgenic fruit flies. These flies had a disorder similar to Alzheimer’s and select groups were given curcumin.<\/p>\n

In comparison to the sick flies who did not receive curcumin, the treatment group lived up to 75 percent longer. They also maintained mobility for longer. However, curcumin did not reduce amyloid plaque formation. This result confirmed the belief that A\u03b2 oligomers<\/a> are the most harmful to nerve cells.<\/p>\n

Reducing the Impact of Aging on Your Brain<\/h1>\n

If age is the greatest factor for dementia, then it is important to intervene. Aging is inevitable, but it is possible to slow down the progression of this natural process. While focusing specifically on the brain, one 2017 study<\/a> is of particular interest. Based on previous research, three main interventions were outlined.<\/p>\n

These include:<\/p>\n