{"id":5827,"date":"2018-06-15T14:01:34","date_gmt":"2018-06-15T14:01:34","guid":{"rendered":"http:\/\/braintest.com\/?p=5827"},"modified":"2019-12-06T20:01:47","modified_gmt":"2019-12-06T20:01:47","slug":"sex-differences-men-women-believed-impact-alzheimers-risk","status":"publish","type":"post","link":"https:\/\/braintest.com\/es\/sex-differences-men-women-believed-impact-alzheimers-risk\/","title":{"rendered":"Sex Differences Between Men and Women Are Believed to Impact Alzheimer’s Risk"},"content":{"rendered":"

When it comes to disease, including Alzheimer\u2019s, sex matters. However, according to a recent paper<\/a> published in <\/span><\/span>Alzheimer\u2019s & Dementia<\/i><\/span><\/span>, a clear research gap exists.\u00a0This area of research could better prevent, diagnose, and treat both men and women. <\/span><\/span><\/span><\/p>\n

At this time, Alzheimer\u2019s is the fifth leading cause of death among women and the eighth leading cause for men. By addressing the sociocultural and biological differences between men and women, this may potentially speed up the development of new treatment options. <\/span><\/p>\n

Biological Differences Play a Key Role in the Progression of Alzheimer\u2019s<\/span><\/span><\/p>\n

As stated in one review<\/a>, <\/span><\/span>The evolution of sex differences in disease, <\/i><\/span><\/span>men and women differ in terms of rates of incidence, the age of onset, and symptoms. Of the approximately 5.7 million Americans currently living with Alzheimer’s, two-thirds are women. <\/span><\/span><\/span><\/p>\n

Although progress has been made in recent years, these sex differences\u00a0receive little attention. Traditionally, hormonal differences have been closely studied. However, based on prior research, the impact of sex-chromosomes and hormones cannot be the only explanation. <\/span><\/span><\/p>\n

While focusing specifically on Alzheimer\u2019s, it is clear that biological sex plays a role in relation to one\u2019s overall risk. For example, APOE4 is a well-known, common genetic risk factor. However, women who carry this gene variation are more likely to develop Alzheimer\u2019s than men who carry APOE4. <\/span><\/p>\n

Although researchers are unsure why, after receiving a diagnosis, women tend to decline more rapidly than men. Women also tend to display more outward signs of dementia than men, even when their pathology is the same (i.e. the presence of plaques and tangles in the brain). <\/span><\/p>\n

High priority areas of research <\/span><\/span><\/h3>\n

At this time, there are a number of high priority research areas, including:<\/span><\/span><\/p>\n